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- <text id=93TT0945>
- <title>
- Jan. 25, 1993: Waking Up Genes
- </title>
- <history>
- TIME--The Weekly Newsmagazine--1993
- Jan. 25, 1993 Stand and Deliver: Bill Clinton
- </history>
- <article>
- <source>Time Magazine</source>
- <hdr>
- THE WEEK
- HEALTH & SCIENCE, Page 23
- Waking Up Genes
- </hdr>
- <body>
- <p>A flavor enhancer may provide the first treatment for sickle-cell
- anemia
- </p>
- <p> Occasionally, greatness emerges from the commonplace.
- Scientists have found that an ordinary food additive may help
- people who suffer from sickle-cell anemia, the inherited illness
- that afflicts up to 100,000 black Americans. A preliminary study
- in the New England Journal of Medicine suggests that butyrate,
- a widely used flavor enhancer, can overcome the basic cause of
- the disease. A genetic flaw leads the body to make abnormal
- hemoglobin, the blood protein that carries essential oxygen.
- </p>
- <p> Six patients with either sickle-cell anemia or
- thalassemia, a related blood disorder, showed dramatic
- improvement after receiving butyrate injections for two to three
- weeks. Apparently the chemical reactivates a gene that produces
- a form of hemoglobin used by the baby in the womb but shuts down
- soon after birth. Turned on again, the gene directs the
- manufacture of enough fetal hemoglobin to compensate for the
- defective adult variety.
- </p>
-
- </body>
- </article>
- </text>
-
-